Nitric Oxide-Releasing NO–Curcumin Hybrid Inhibits Colon Cancer Cell Proliferation and Induces Cell Death In Vitro

Cancer is a leading cause of death worldwide, and most the currently available drugs for cancer treatment have limited potential. Natural products their relatives continue to represent very high percentage used treatment. Curcumin one several natural that has recently attracted much attention due its putative cancer-preventive anticancer properties. As well, Nitric Oxide (NO) holds great potential NO-based treatments wide variety diseases. Here, first time, we tested anti-cancer activities an NO–Curcumin hybrid, hypothesizing by joining effects curcumin NO in compound, hybrid compound would be more potent than alone treating colon cancer. To compare NO–curcumin, treated different cell lines with either or NO–curcumin on proliferation death. Our results show effective reducing increasing when compared curcumin. In addition, lower IC50 Altogether, our demonstrate time activity alone, making it future perhaps other